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The fluorinase from Streptomyces cattleya is also a chlorinase.

作者信息

Deng Hai, Cobb Steven L, McEwan Andrew R, McGlinchey Ryan P, Naismith James H, O'Hagan David, Robinson David A, Spencer Jonathan B

机构信息

School of Chemistry and Centre for Biomolecular Science, University of St Andrews, St Andrews, KY16 9ST, UK.

出版信息

Angew Chem Int Ed Engl. 2006 Jan 23;45(5):759-62. doi: 10.1002/anie.200503582.

Abstract
摘要

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本文引用的文献

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Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination.
Science. 2005 Sep 30;309(5744):2216-9. doi: 10.1126/science.1116510.
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Insight into enzymatic C-F bond formation from QM and QM/MM calculations.
J Am Chem Soc. 2005 Oct 5;127(39):13643-55. doi: 10.1021/ja053875s.
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Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.
Nature. 2005 Aug 25;436(7054):1191-4. doi: 10.1038/nature03797.
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Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya.
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Crystal structure and mechanism of a bacterial fluorinating enzyme.
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