一种酶促 Finkelstein 反应：氟酶催化直接卤素交换。
An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange.
机构信息
School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK.
Now at Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
出版信息
Org Biomol Chem. 2019 Aug 28;17(32):7493-7496. doi: 10.1039/c9ob01625b. Epub 2019 Jul 31.
The fluorinase enzyme from Streptomyces cattleya is shown to catalyse a direct displacement of bromide and iodide by fluoride ion from 5'-bromodeoxyadenosine (5'-BrDA) and 5'-iododeoxyadenosine (5'-IDA) respectively to form 5'-fluorodeoxyadenosine (5'-FDA) in the absence of l-methionine (l-Met) or S-adenosyl-l-methionine (SAM). 5'-BrDA is the most efficient substrate for this enzyme catalysed Finkelstein reaction.
链霉菌属卡特利链霉菌的氟化物酶被证明能够催化 5'-溴脱氧腺苷（5'-BrDA）和 5'-碘脱氧腺苷（5'-IDA）分别将溴离子和碘离子直接取代为氟离子，从而在没有 l-蛋氨酸（l-Met）或 S-腺苷-l-蛋氨酸（SAM）的情况下形成 5'-氟脱氧腺苷（5'-FDA）。对于该酶催化的 Finkelstein 反应，5'-BrDA 是最有效的底物。
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