Houlgatte A, Bauduceau O
Clinique urologique, hôpital d'instruction des Armées du Val de Grâce, 74, boulevard de Port-Royal, 75005 Paris, France.
Ann Urol (Paris). 2005 Oct;39(5):159-69. doi: 10.1016/j.anuro.2005.09.004.
Among germ cell tumours, seminomas hold a particular status related to their radio-sensitivity. Although radiotherapy remains the best treatment for Localized tumours of stage 1, in some cases, surveillance or chemotherapy may presently be considered as alternative therapies. Due to Long-term radiotherapy-related adverse effects, in particular the risk of second non-germ malignancies or cardiac morbidity, both dose and irradiation field are reduced in case of lymphatic retroperitoneal extension. Chemotherapy is the preferential treatment in more advanced stages, either with retroperitoneal bulky disease or with metastatic extension. Its efficacy allows Limiting surgical indications on residual masses, relying partly on the follow-up data of positron emission transaxial tomography assessment.
在生殖细胞肿瘤中，精原细胞瘤因其放射敏感性而具有特殊地位。尽管放射治疗仍然是1期局限性肿瘤的最佳治疗方法，但在某些情况下，目前可将监测或化疗视为替代疗法。由于长期放疗相关的不良反应，特别是发生第二种非生殖系统恶性肿瘤或心脏疾病的风险，在出现腹膜后淋巴结转移时，放疗剂量和照射野均会减少。化疗是更晚期病例的首选治疗方法，无论是伴有腹膜后大块病灶还是有远处转移。其疗效使得可以限制对残留肿块的手术指征，部分依赖于正电子发射断层扫描评估的随访数据。
