降钙素基因相关肽作为大鼠小脑发育过程中攀缘纤维的标志物。

CGRP as a marker of the climbing fibers during the development of the cerebellum in the rat.

作者信息

Morara S, Rosina A, Provini L

机构信息

Ist. Fisiologia Centri Nervosi CNR, Facoltá di Farmacia, Universitá di Milano, Italy.

出版信息

Ann N Y Acad Sci. 1992 Jun 30;657:461-3. doi: 10.1111/j.1749-6632.1992.tb22800.x.

DOI:10.1111/j.1749-6632.1992.tb22800.x

PMID:1637100

Abstract

Olivary fibers express CGRP-LI until the nest phase of their development and never in the next postnatal steps, that is, the "capuchon" stage. Together with other results presented in this volume regarding the postnatal development of CGRP binding sites in the cerebellar cortex, these immunohistologic findings suggest a role for CGRP in reshaping connectivity and in synapse stabilization of cerebellar circuitry during postnatal development.

摘要

橄榄纤维在其发育的巢状阶段之前表达降钙素基因相关肽样免疫反应物（CGRP-LI），而在出生后的后续阶段，即“帽状”阶段则不再表达。结合本卷中关于小脑皮质降钙素基因相关肽（CGRP）结合位点出生后发育的其他结果，这些免疫组织学发现提示CGRP在出生后发育过程中对小脑回路的重塑连接性和突触稳定起作用。