Ju G, Ma D, Fan S C
Department of Neurobiology, Fourth Military Medical University, Xi'an, PR China.
Neuroendocrinology. 1994 May;59(5):505-10. doi: 10.1159/000126697.
The mammalian anterior pituitary is known to be regulated by humoral factors only, no direct neural influence having ever been discovered. Our recent studies have shown in several species that there are substantial amounts of substance P and calcitonin-gene-related peptide-like immunoreactive (CGRP-LI) nerve fibers in the anterior pituitary and that they can make synaptic contacts with secretory cells, among which corticotropes. In the present study, we investigated changes in CGRP-LI nerve fibers of the anterior pituitary after bilateral adrenalectomy in the rat. The results show that the number of CGRP-LI nerve fibers increases significantly. In parallel, they cover a wider area of the gland after the operation, suggesting a direct neural influence.
已知哺乳动物的垂体前叶仅受体液因子调节，从未发现有直接的神经影响。我们最近的研究表明，在几个物种中，垂体前叶存在大量的P物质和降钙素基因相关肽样免疫反应性（CGRP-LI）神经纤维，并且它们可以与分泌细胞形成突触联系，其中包括促肾上腺皮质激素细胞。在本研究中，我们调查了大鼠双侧肾上腺切除术后垂体前叶CGRP-LI神经纤维的变化。结果表明，CGRP-LI神经纤维的数量显著增加。同时，术后它们覆盖了腺体内更广泛的区域，提示存在直接的神经影响。
