Zohar Edna, Luban Ilia, White Paul F, Ramati Erez, Shabat Shay, Fredman Brian
Department of Anesthesiology, Meir Hospital, Kfar Saba, Israel.
Can J Anaesth. 2006 Jan;53(1):20-5. doi: 10.1007/BF03021523.
To assess if titration of sevoflurane using the bispectral index (BIS) monitor improves the early and intermediate recovery in geriatric outpatients undergoing brief urologic procedures under general anesthesia without muscle relaxants.
After a standardized induction with propofol and fentanyl, a laryngeal mask airway was inserted and sevoflurane was administered in combination with 60% nitrous oxide in oxygen for maintenance of anesthesia in spontaneously breathing outpatients. In the Control group (n = 25), sevoflurane and fentanyl were titrated according to standard clinical practice. In the BIS-directed group (n = 25), sevoflurane was titrated to maintain a BIS value between 50 and 60, and supplemental fentanyl, 25 mug iv boluses were administered to treat tachypnea. The intraoperative anesthetic and analgesic requirements, as well as the times to eye opening, removal of the laryngeal mask airway device, response to simple commands, orientation to person and place, and postanesthesia care unit discharge eligibility (fast-track score of 14) were assessed at specific time intervals.
The minimum alveolar concentration-hour of sevoflurane (0.25 +/- 0.15 and 0.31 +/- 0.2) and end-tidal concentrations of sevoflurane at the end of surgery (0.3 +/- 0.3 and 0.4 +/- 0.20%) did not differ significantly between the Control and BIS-directed groups, respectively. Although the percentage of patients requiring supplemental boluses of fentanyl was reduced in the BIS-directed group (16 vs 48%, P <0.05), the intraoperative BIS values and recovery times were similar in the two groups.
In this non-paralyzed elderly outpatient surgery population, the use of BIS monitoring for titrating the maintenance anesthetic (sevoflurane) failed to improve the early recovery process.
评估在无肌肉松弛剂的全身麻醉下接受简短泌尿外科手术的老年门诊患者中,使用脑电双频指数(BIS)监测仪滴定七氟醚是否能改善早期和中期恢复情况。
在使用丙泊酚和芬太尼进行标准化诱导后,插入喉罩气道,并将七氟醚与60%氧化亚氮-氧气混合用于自主呼吸门诊患者的麻醉维持。在对照组(n = 25)中,七氟醚和芬太尼根据标准临床实践进行滴定。在BIS指导组(n = 25)中,滴定七氟醚以维持BIS值在50至60之间,静脉注射25μg芬太尼推注用于治疗呼吸急促。在特定时间间隔评估术中麻醉和镇痛需求,以及睁眼时间、喉罩气道装置移除时间、对简单指令的反应、人物和地点定向,以及麻醉后恢复室出院资格(快速康复评分为14)。
七氟醚的最低肺泡浓度-小时(分别为0.25±0.15和0.31±0.2)以及手术结束时七氟醚的呼气末浓度(分别为0.3±0.3和0.4±0.20%)在对照组和BIS指导组之间无显著差异。虽然BIS指导组中需要补充芬太尼推注的患者百分比降低(16%对48%,P<0.05),但两组术中BIS值和恢复时间相似。
在这个未使用肌肉松弛剂的老年门诊手术人群中,使用BIS监测滴定维持麻醉(七氟醚)未能改善早期恢复过程。