土耳其儿童继发性噬血细胞性淋巴组织细胞增生症
Secondary hemophagocytic lymphohistiocytosis in Turkish children.
作者信息
Gurgey Aytemiz, Secmeer Gulten, Tavil Betul, Ceyhan Mehmet, Kuskonmaz Baris, Cengiz Bulent, Ozen Hasan, Kara Ates, Cetin Mualla, Gumruk Fatma
机构信息
Pediatric Hematology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
出版信息
Pediatr Infect Dis J. 2005 Dec;24(12):1116-7. doi: 10.1097/01.inf.0000190043.48182.31.
Between January 1998 and January 2005, a total of 18 children 2 weeks-72 months of age were diagnosed as having secondary hemophagocytic lymphohistiocytosis. The frequency of secondary hemophagocytic lymphohistiocytosis among total hospitalized patients during this period was 0.05% (18 of 34,250). Of the 18 patients, 8 (44.5%) had bacterial infections; cytomegalovirus and Epstein-Barr virus infections were present in 5 (28%) and 1 (5.5%), patient, respectively. Leishmaniasis was diagnosed in 2 patients (11%), and herpes simplex virus was diagnosed in 2 patients (11%). Six patients died during treatment, and 1 patient was lost to follow-up. The survival rate was 61%.
1998年1月至2005年1月期间，共有18名年龄在2周-72个月的儿童被诊断为继发性噬血细胞性淋巴组织细胞增生症。在此期间，继发性噬血细胞性淋巴组织细胞增生症在全部住院患者中的发生率为0.05%（34250例中有18例）。18例患者中，8例（44.5%）有细菌感染；巨细胞病毒和EB病毒感染分别见于5例（28%）和1例（5.5%）患者。2例患者（11%）被诊断为利什曼病，2例患者（11%）被诊断为单纯疱疹病毒感染。6例患者在治疗期间死亡，1例患者失访。生存率为61%。
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