内脏利什曼病患儿的噬血细胞性淋巴组织细胞增生症
Hemophagocytic lymphohistiocytosis in children with visceral leishmaniasis.
作者信息
Blázquez-Gamero Daniel, Domínguez-Pinilla Nerea, Chicharro Carmen, Negreira Sagrario, Galán Pilar, Pérez-Gorricho Beatriz, Calvo Cristina, Prieto Luis, De la Parte María, Otheo Enrique, Vivanco Jose Luis, Ruiz-Contreras Jesús
机构信息
From the *Pediatric Infectious Diseases and Immunodeficiencies Unit, 12 de Octubre University Hospital, Madrid, Spain; †Pediatric Hematology/Oncology Unit, 12 de Octubre University Hospital, Madrid, Spain; ‡WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain; §Department of Pediatrics, Fuenlabrada University Hospital, Fuenlabrada, Spain; ¶Pediatric Infectious Diseases Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; ‖Department of Pediatrics, Severo Ochoa University Hospital, Leganés, Spain; **Department of Pediatrics, Getafe University Hospital, Getafe, Spain; ††Department of Pediatrics, Móstoles University Hospital, Móstoles, Spain; and ‡‡Department of Pediatrics, Ramón y Cajal University Hospital, Madrid, Spain.
出版信息
Pediatr Infect Dis J. 2015 Jun;34(6):667-9. doi: 10.1097/INF.0000000000000685.
Acquired hemophagocytic lymphohistiocitosis (HLH) syndrome can be a complication of visceral leishmaniasis (VL). A multicenter prospective study was conducted to determine the frequency of HLH syndrome in children with VL. Twenty-four children with VL were identified, and 10 (41%) developed HLH syndrome. VL should be ruled out in all children with HLH criteria living in or coming from endemic areas.
获得性噬血细胞性淋巴组织细胞增生症（HLH）综合征可能是内脏利什曼病（VL）的一种并发症。开展了一项多中心前瞻性研究，以确定VL患儿中HLH综合征的发生率。共确定了24例VL患儿，其中10例（41%）出现HLH综合征。对于所有符合HLH标准且生活在或来自流行地区的儿童，均应排除VL。
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