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视觉皮层中的伽马波段同步可预测变化检测的速度。

Gamma-band synchronization in visual cortex predicts speed of change detection.

作者信息

Womelsdorf Thilo, Fries Pascal, Mitra Partha P, Desimone Robert

机构信息

FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands.

出版信息

Nature. 2006 Feb 9;439(7077):733-6. doi: 10.1038/nature04258. Epub 2005 Dec 21.

Abstract

Our capacity to process and respond behaviourally to multiple incoming stimuli is very limited. To optimize the use of this limited capacity, attentional mechanisms give priority to behaviourally relevant stimuli at the expense of irrelevant distractors. In visual areas, attended stimuli induce enhanced responses and an improved synchronization of rhythmic neuronal activity in the gamma frequency band (40-70 Hz). Both effects probably improve the neuronal signalling of attended stimuli within and among brain areas. Attention also results in improved behavioural performance and shortened reaction times. However, it is not known how reaction times are related to either response strength or gamma-band synchronization in visual areas. Here we show that behavioural response times to a stimulus change can be predicted specifically by the degree of gamma-band synchronization among those neurons in monkey visual area V4 that are activated by the behaviourally relevant stimulus. When there are two visual stimuli and monkeys have to detect a change in one stimulus while ignoring the other, their reactions are fastest when the relevant stimulus induces strong gamma-band synchronization before and after the change in stimulus. This enhanced gamma-band synchronization is also followed by shorter neuronal response latencies on the fast trials. Conversely, the monkeys' reactions are slowest when gamma-band synchronization is high in response to the irrelevant distractor. Thus, enhanced neuronal gamma-band synchronization and shortened neuronal response latencies to an attended stimulus seem to have direct effects on visually triggered behaviour, reflecting an early neuronal correlate of efficient visuo-motor integration.

摘要

我们处理多个传入刺激并做出行为反应的能力非常有限。为了优化这种有限能力的使用,注意力机制会优先处理与行为相关的刺激,而忽略无关的干扰因素。在视觉区域,被关注的刺激会诱导反应增强,并改善伽马频段(40-70赫兹)有节奏的神经元活动的同步性。这两种效应可能都改善了大脑区域内和区域间被关注刺激的神经元信号传递。注意力还会导致行为表现改善和反应时间缩短。然而,尚不清楚反应时间与视觉区域的反应强度或伽马频段同步性之间有何关系。在这里,我们表明,对刺激变化的行为反应时间可以通过猴子视觉区域V4中那些被行为相关刺激激活的神经元之间的伽马频段同步程度来具体预测。当有两个视觉刺激,猴子必须检测其中一个刺激的变化而忽略另一个时,当相关刺激在刺激变化前后诱导出强烈的伽马频段同步时,它们的反应最快。在快速试验中,这种增强的伽马频段同步还伴随着较短的神经元反应潜伏期。相反,当对无关干扰物的伽马频段同步性较高时,猴子的反应最慢。因此,增强的神经元伽马频段同步和对被关注刺激缩短的神经元反应潜伏期似乎对视觉触发行为有直接影响,反映了高效视觉-运动整合的早期神经元关联。

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