Erenpreiss J, Spano M, Erenpreisa J, Bungum M, Giwercman A
University of Lund, Fertility Centre, Malmö University Hospital, Malmö SE 205 02, Sweden.
Asian J Androl. 2006 Jan;8(1):11-29. doi: 10.1111/j.1745-7262.2006.00112.x.
Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.
精子染色质/DNA完整性对于父系遗传信息的准确传递至关重要，正常的精子染色质结构对精子受精能力也很重要。精液常规检查，包括精子浓度、活力和形态，无法识别精子染色质结构的缺陷。本文描述了精子DNA损伤的起源及其各种评估方法。评估精子DNA损伤似乎是评估体内和体外男性生育潜力的有用工具。本文还讨论了精子DNA缺陷对后代可能产生的影响。
