Murphy Timothy F
University at Buffalo, State University of New York, Medical Research 151, Buffalo VAMC, 3495 Bailey Avenue, Buffalo, NY 14215, USA.
Expert Rev Vaccines. 2005 Dec;4(6):843-53. doi: 10.1586/14760584.4.6.843.
An urgent need exists for vaccines to prevent infections caused by nontypeable Haemophilus influenzae and Moraxella catarrhalis. These bacteria cause otitis media in children, a clinical problem associated with enormous morbidity and cost. H. influenzae and M. catarrhalis also cause lower respiratory tract infections in adults with chronic lung disease. Infections in this clinical setting are associated with disability and death. Recent progress in identifying potential vaccine antigens in both bacteria raises great promise in developing effective vaccines. This paper reviews the key issues in vaccine development for H. influenzae and M. catarrhalis, including areas where progress has been stalled, and proposes areas that deserve investigation in the next 5 years.
迫切需要预防由不可分型流感嗜血杆菌和卡他莫拉菌引起感染的疫苗。这些细菌可导致儿童中耳炎，这是一个与高发病率和高成本相关的临床问题。流感嗜血杆菌和卡他莫拉菌还可引起慢性肺病成人的下呼吸道感染。这种临床情况下的感染与残疾和死亡相关。近期在确定这两种细菌潜在疫苗抗原方面取得的进展为开发有效疫苗带来了巨大希望。本文综述了流感嗜血杆菌和卡他莫拉菌疫苗开发中的关键问题，包括进展停滞的领域，并提出了未来5年值得研究的领域。
