预防 HIV 疫苗的发展现状。
Current situation in the development of a preventive HIV vaccine.
机构信息
Unidad de Inmunopatología del Sida, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, España.
出版信息
Enferm Infecc Microbiol Clin. 2005 Jul;23 Suppl 2:5-24. doi: 10.1016/S0213-005X(05)75156-9.
The uncontrolled progression of the AIDS epidemic has made the development of an efficacious human immunodeficiency virus (HIV) vaccine a major objective of scientific research. No effective preventive vaccine against HIV is currently available and sterilizing immunity has not yet been achieved in animal models. This review analyses the major challenges in developing an AIDS vaccine, in particular the mechanisms involved in viral escape from the immune response, and summarizes the results obtained with the different prototypes of therapeutic and preventive vaccines. Finally, social, economic and healthcare aspects of research into HIV vaccines and current controversies regarding the development of clinical trials are discussed.
艾滋病疫情的失控使得研发有效的人类免疫缺陷病毒（HIV）疫苗成为科学研究的主要目标。目前尚无有效的预防性 HIV 疫苗，动物模型中也尚未实现能完全清除病毒的免疫。本文分析了研发艾滋病疫苗的主要挑战，特别是病毒逃避免疫反应的机制，并总结了不同治疗性和预防性疫苗原型的研究结果。最后，讨论了 HIV 疫苗研究的社会、经济和医疗保健方面，以及目前临床试验开发方面的争议。
Zotero 插件