Grant D, Long W F, Williamson F B
Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, Scotland, U.K.
Biochem J. 1992 Jul 15;285 ( Pt 2)(Pt 2):477-80. doi: 10.1042/bj2850477.
Potentiometric titrations, at ionic strengths (I) ranging from 0.0057 to 0.336, suggest that Ca2+, Cu2+, Li+ and Na+ bind to heparin in a manner that depends on cation identity. These interactions were less affected by the value of I than those of heparin with Mg2+, which binds weakly below I0.050 and with K+, which binds weakly at I0.0057. Of the interactions studied, that of heparin with Cu2+ was the least readily reversible.
在离子强度（I）范围为0.0057至0.336的电位滴定表明，Ca2+、Cu2+、Li+和Na+与肝素的结合方式取决于阳离子的特性。与肝素和Mg2+（在I<0.050时结合较弱）以及肝素和K+（在I = 0.0057时结合较弱）的相互作用相比，这些相互作用受I值的影响较小。在所研究的相互作用中，肝素与Cu2+的相互作用最难逆转。
