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放疗治疗D1期前列腺癌时淋巴结受累范围的预后意义

Prognostic significance of extent of nodal involvement in stage D1 prostate cancer treated with radiotherapy.

作者信息

Anscher M S, Prosnitz L R

机构信息

Duke Comprehensive Cancer Center, Duke University Medical Center, Division of Radiation Oncology, Durham, North Carolina.

出版信息

Urology. 1992 Jan;39(1):39-43. doi: 10.1016/0090-4295(92)90038-x.

DOI:10.1016/0090-4295(92)90038-x
PMID:1637367
Abstract

The records of 107 patients with newly diagnosed adenocarcinoma of the prostate irradiated with curative intent at Duke University Medical Center from 1970 through 1983 were reviewed. Forty patients (37%) underwent standard bilateral pelvic lymph node dissection (PLND) prior to beginning irradiation. Twenty-four patients (22%) were found to have pelvic nodal metastases (Stage D1). Those found to have a single microscopically positive node at PLND may be curable with irradiation. In contrast, those with more extensive nodal metastases appear to be incurable with radiotherapy. Additional studies are needed to confirm or refute these findings.

摘要

回顾了1970年至1983年在杜克大学医学中心接受根治性放疗的107例新诊断前列腺腺癌患者的记录。40例患者(37%)在开始放疗前接受了标准的双侧盆腔淋巴结清扫术(PLND)。24例患者(22%)被发现有盆腔淋巴结转移(D1期)。那些在PLND中发现单个显微镜下阳性淋巴结的患者可能通过放疗治愈。相比之下,那些有更广泛淋巴结转移的患者似乎无法通过放疗治愈。需要进一步的研究来证实或反驳这些发现。

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引用本文的文献

1
Early versus deferred androgen suppression therapy for patients with lymph node-positive prostate cancer after local therapy with curative intent: a systematic review.根治性局部治疗后淋巴结阳性前列腺癌患者的早期与延迟雄激素抑制治疗:系统评价。
BMC Cancer. 2013 Mar 19;13:131. doi: 10.1186/1471-2407-13-131.
2
[Locally advanced prostate carcinoma (T2b-T4 N0) without and with clinical evidence of local progression (Tx N+) with lymphatic metastasis. Is radiotherapy for pelvic lymphatic metastasis indicated or not?].[局部进展期前列腺癌(T2b - T4 N0),有无局部进展的临床证据(Tx N+)伴淋巴转移。盆腔淋巴转移是否需要进行放射治疗?]
Strahlenther Onkol. 1998 May;174(5):231-6. doi: 10.1007/BF03038714.
3
[Radiotherapy after radical prostatectomy: indications, results and side effects].
前列腺癌根治术后放疗:适应证、疗效及副作用
Strahlenther Onkol. 1997 Jun;173(6):309-15. doi: 10.1007/BF03038913.