Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S
Groupe Matrice Extracellulaire et Biominéralisation, Université Paris 5, France.
J Dent Res. 2006 Jan;85(1):22-32. doi: 10.1177/154405910608500104.
The objective of this review is to summarize our understanding of the role of host matrix metalloproteinases (MMPs) in the caries process and to discuss new therapeutic avenues. MMPs hydrolyze components of the extracellular matrix and play a central role in many biological and pathological processes. MMPs have been suggested to play an important role in the destruction of dentin organic matrix following demineralization by bacterial acids and, therefore, in the control or progression of carious decay. Host-derived MMPs can originate both from saliva and from dentin. They may be activated by an acidic pH brought about by lactate release from cariogenic bacteria. Once activated, they are able to digest demineralized dentin matrix after pH neutralization by salivary buffers. Furthermore, the degradation of SIBLINGs (Small Integrin-binding Ligand N-linked Glycoproteins) by the caries process may potentially enhance the release of MMPs and their activation. This review also explores the different available MMP inhibitors, natural or synthetic, and suggests that MMP inhibition by several inhibitors, particularly by natural substances, could provide a potential therapeutic pathway to limit caries progression in dentin.
本综述的目的是总结我们对宿主基质金属蛋白酶（MMPs）在龋病过程中作用的理解，并探讨新的治疗途径。MMPs可水解细胞外基质的成分，并在许多生物和病理过程中发挥核心作用。有人提出，MMPs在细菌酸脱矿后牙本质有机基质的破坏中起重要作用，因此在龋病的控制或进展中也起重要作用。宿主来源的MMPs可源自唾液和牙本质。它们可能被致龋菌释放的乳酸所导致的酸性pH激活。一旦被激活，它们能够在唾液缓冲液中和pH后消化脱矿的牙本质基质。此外，龋病过程对小整合素结合配体N-连接糖蛋白（SIBLINGs）的降解可能会潜在地增强MMPs的释放及其激活。本综述还探讨了不同的可用MMP抑制剂，包括天然的和合成的，并表明几种抑制剂，特别是天然物质对MMPs的抑制作用，可能为限制牙本质龋病进展提供一条潜在的治疗途径。
