Pizzi Laura T, Weston Christine M, Goldfarb Neil I, Moretti Deborah, Cobb Nicole, Howell Jamie B, Infantolino Anthony, Dimarino Anthony J, Cohen Sidney
Department of Health Policy, Jefferson Medical College, Philadelphia, PA 19107, USA.
Inflamm Bowel Dis. 2006 Jan;12(1):47-52. doi: 10.1097/01.mib.0000191670.04605.e7.
Although studies suggest that inflammatory bowel disease (IBD) has a significant impact on an individual's health-related quality of life, the added weight of other health conditions and comorbidities has not been investigated. The purpose of this study was to expand on prior research by taking into account the impact of other chronic health conditions on the health-related quality of life of individuals with IBD, and to develop a model to help clinicians understand the relative impact of various predictors of their patients' physical and mental health-related quality of life.
615 patients from the gastroenterology outpatient practice of a large, urban university hospital received a self-administered survey including questions about their health conditions, the severity of their bowel symptoms, and their health-related quality of life (measured using the SF-36 instrument).
314 completed surveys were returned, resulting in a response rate of 51.1%. Two regression analyses were conducted to identify the role of patient demographic variables and other chronic conditions on the 2 primary outcomes of interest: the SF-36 Physical Component and Mental Component Summary scores. Statistically significant predictors of physical quality of life included IBD disease severity, arthritis, heart disease, age, anemia, back/shoulder pain, and hypertension; statistically significant predictors of mental health-related quality of life were IBD disease severity, depression/anxiety, age, and headaches.
IBD disease severity is the most important predictor of both physical and mental health-related quality of life in patients with this condition despite the presence of other chronic conditions.
尽管研究表明炎症性肠病（IBD）对个体的健康相关生活质量有重大影响，但其他健康状况和合并症的附加影响尚未得到研究。本研究的目的是在先前研究的基础上，考虑其他慢性健康状况对IBD患者健康相关生活质量的影响，并建立一个模型，以帮助临床医生了解各种预测因素对其患者身心健康相关生活质量的相对影响。
来自一家大型城市大学医院胃肠病门诊的615名患者接受了一项自我管理的调查，其中包括关于他们的健康状况、肠道症状严重程度以及他们的健康相关生活质量（使用SF-36量表进行测量）的问题。
共收回314份完整的调查问卷，回复率为51.1%。进行了两项回归分析，以确定患者人口统计学变量和其他慢性疾病对两个主要关注结果的作用：SF-36身体成分和心理成分总结得分。身体健康相关生活质量的统计学显著预测因素包括IBD疾病严重程度、关节炎、心脏病、年龄、贫血、背部/肩部疼痛和高血压；心理健康相关生活质量的统计学显著预测因素是IBD疾病严重程度、抑郁/焦虑、年龄和头痛。
尽管存在其他慢性疾病，但IBD疾病严重程度是该疾病患者身心健康相关生活质量的最重要预测因素。
