Kalichman Seth C, Cain Demetria, Cherry Charsey, Kalichman Moira, Pope Howard
Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA.
AIDS Patient Care STDS. 2005 Dec;19(12):833-9. doi: 10.1089/apc.2005.19.833.
HIV treatment adherence is improved by behavioral interventions, including medication organizers such as pillboxes, which can also interfere with adherence electronic monitoring devices (EMD). This study examined the characteristics of pillbox users and the implications of pillbox use for research using EMD adherence research. Men and women (n = 160) currently taking antiretroviral medications (ARVs) completed anonymous surveys in a community research setting. Sixty-three (39%) of individuals taking ARVs were currently using a pillbox. Pillbox users were significantly more likely to have an undetectable viral load and less likely to have missed their medications within a day of the assessment. Pillbox users indicated feeling that they benefited from using their pillbox and 76% reported they would likely stop using their pillbox if required to participate in a research study that paid them. Adherence EMD pose methodological limitations to research when pillbox users are excluded and ethical implications when pillbox users stop using their pillbox to participate.
行为干预措施，包括使用药盒等药物管理工具，可提高艾滋病病毒（HIV）治疗的依从性，但药盒也可能干扰依从性电子监测设备（EMD）。本研究调查了药盒使用者的特征，以及使用药盒对采用EMD进行依从性研究的影响。在社区研究环境中，160名正在服用抗逆转录病毒药物（ARV）的男性和女性完成了匿名调查。正在服用ARV的个体中有63人（39%）目前正在使用药盒。药盒使用者的病毒载量更有可能检测不到，且在评估前一天内漏服药物的可能性更小。药盒使用者表示感觉从使用药盒中受益，76%的人报告称，如果被要求参加一项付费的研究，他们可能会停止使用药盒。当排除药盒使用者时，依从性EMD会给研究带来方法学上的限制；而当药盒使用者为了参与研究而停止使用药盒时，则会产生伦理问题。
