Sheppard David P, Weber Erica, Casaletto Kaitlin B, Avci Gunes, Woods Steven Paul
J Assoc Nurses AIDS Care. 2016 Sep-Oct;27(5):595-607. doi: 10.1016/j.jana.2016.03.006. Epub 2016 Apr 6.
Prospective memory (PM) is associated with antiretroviral (ARV) adherence in HIV, but little is known about how pill burden and age might affect this association. One hundred seventeen older (≥50 years) and 82 younger (<50 years) HIV-infected adults were administered a measure of PM in the laboratory and subsequently were monitored for ARV adherence for 30 days using the Medication Event Monitoring System. In the older group, better time-based PM performance was associated with higher likelihood of adherence, irrespective of pill burden. Within the younger sample, time-based PM was positively related to adherence only in participants with lower pill burdens. Younger HIV-infected individuals with higher pill burdens may overcome the normal effects of time-based PM on adherence through compensatory medication-taking strategies, whereas suboptimal use of these strategies by younger HIV-infected individuals with lower pill burdens may heighten their risk of ARV nonadherence secondary to deficits in time-based PM.
前瞻性记忆（PM）与HIV感染者的抗逆转录病毒（ARV）治疗依从性相关，但对于药片负担和年龄如何影响这种关联却知之甚少。117名年龄较大（≥50岁）和82名年龄较小（<50岁）的HIV感染成人在实验室中接受了前瞻性记忆测试，随后使用药物事件监测系统对他们的ARV治疗依从性进行了30天的监测。在年龄较大的组中，无论药片负担如何，基于时间的前瞻性记忆表现越好，依从性的可能性就越高。在较年轻的样本中，只有在药片负担较低的参与者中，基于时间的前瞻性记忆与依从性呈正相关。药片负担较高的年轻HIV感染者可能通过补偿性服药策略克服基于时间的前瞻性记忆对依从性的正常影响，而药片负担较低的年轻HIV感染者对这些策略使用不当，可能会因基于时间的前瞻性记忆缺陷而增加抗逆转录病毒治疗不依从的风险。
