Fujimoto Naohiro, Nomura Masayoshi, Matsumoto Tetsuro
Department of Urology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka Yahatanishi Kitakyushu, 807-8555, Japan.
Expert Rev Anticancer Ther. 2006 Jan;6(1):59-71. doi: 10.1586/14737140.6.1.59.
Prostate cancer remains one of the most common malignancies in Western countries and is also increasing in Asian countries. The high incidence, influence of environmental factors, such as androgen, and extended natural history of prostate cancer provide multiple opportunities for prevention; therefore prostate cancer is an ideal candidate for chemoprevention. The development of chemoprevention strategies against prostate cancer would have a huge impact, both medically and economically. Large-scale clinical trials suggest that some agents can prevent the development of prostate cancer. Active research into chemoprevention is ongoing and gathered evidence will provide effective and safe strategies to prevent prostate cancer. This review will highlight the present status of prostate cancer chemoprevention and other mechanisms of prevention, as well as discussing the issues to be addressed.
前列腺癌仍然是西方国家最常见的恶性肿瘤之一，在亚洲国家的发病率也在上升。前列腺癌的高发病率、雄激素等环境因素的影响以及其自然病程较长，为预防提供了多种机会；因此，前列腺癌是化学预防的理想对象。针对前列腺癌的化学预防策略的发展将在医学和经济方面产生巨大影响。大规模临床试验表明，一些药物可以预防前列腺癌的发生。目前针对化学预防的研究正在积极开展，所收集的证据将为预防前列腺癌提供有效且安全的策略。本综述将重点介绍前列腺癌化学预防的现状及其他预防机制，并讨论需要解决的问题。
