Flick Ramon, Bouloy Michèle
University of Texas Medical Branch, Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, 301 University Boulevard, Galveston, TX 77555-0609, USA.
Curr Mol Med. 2005 Dec;5(8):827-34. doi: 10.2174/156652405774962263.
Rift Valley fever is considered to be one of the most important viral zoonoses in Africa. In 2000, the Rift valley fever virus spread to the Arabian Peninsula and caused two simultaneous outbreaks in Yemen and Saudi Arabia. It is transmitted to ruminants and to humans by mosquitoes. The viral agent is an arbovirus, which belongs to the Phlebovirus genus in the Bunyaviridae family. This family of viruses comprises more than 300 members grouped into five genera: Orthobunyavirus, Phlebovirus, Hantavirus, Nairovirus, and Tospovirus. Several members of the Bunyaviridae family are responsible for fatal hemorrhagic fevers: Rift Valley fever virus (Phlebovirus), Crimean-Congo hemorrhagic fever virus (Nairovirus), Hantaan, Sin Nombre and related viruses (Hantavirus), and recently Garissa, now identified as Ngari virus (Orthobunyavirus). Here are reviewed recent advances in Rift Valley fever virus, its epidemiology, molecular biology and focus on recent data on the interactions between viral and cellular proteins, which help to understand the molecular mechanisms utilized by the virus to circumvent the host cellular response.
裂谷热被认为是非洲最重要的病毒性人畜共患病之一。2000年，裂谷热病毒传播到阿拉伯半岛，并在也门和沙特阿拉伯同时引发了两次疫情。它通过蚊子传播给反刍动物和人类。病毒病原体是一种虫媒病毒，属于布尼亚病毒科白蛉病毒属。该病毒科由300多个成员组成，分为五个属：正布尼亚病毒属、白蛉病毒属、汉坦病毒属、内罗病毒属和番茄斑萎病毒属。布尼亚病毒科的几个成员可导致致命性出血热：裂谷热病毒（白蛉病毒属）、克里米亚-刚果出血热病毒（内罗病毒属）、汉坦病毒、辛诺柏病毒及相关病毒（汉坦病毒属），以及最近发现的加里萨病毒，现被确定为恩加里病毒（正布尼亚病毒属）。本文综述了裂谷热病毒的最新研究进展、其流行病学、分子生物学，并重点关注病毒与细胞蛋白相互作用的最新数据，这些数据有助于理解病毒用于规避宿主细胞反应的分子机制。
