Pepeljnjak Stjepan, Zorc Branka, Butula Ivan
Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Acta Pharm. 2005 Dec;55(4):401-8.
Several hydroxamic acids, viz., N-benzyl-N'-hydroxysuccinamide (BHS), poly[alpha,beta-(N-hydroxy)-DL-aspartamide] (PHA), poly[alpha,beta-(N-hydroxy-N-methyl-DL-aspartamide)] (PMHA) and poly[alpha,beta-(N-hydroxy)-DL- aspartamide]/poly[alpha,beta-(N-2-hydroxyethyl)-DL-aspartamide] (PHA-PHEA 1:1) were prepared and screened for their antimicrobial activity. Ten Gram-positive and 7 Gram-negative species of bacteria, 5 Candida species, 4 dermatophyte species and 3 mould species were used in tests. Compound showed no antimicrobial activity on any of the tested microorganisms. Other compounds showed a narrow spectrum of antibacterial activity, but no antifungal activity.
制备了几种异羟肟酸，即N-苄基-N'-羟基琥珀酰胺（BHS）、聚[α,β-(N-羟基)-DL-天冬酰胺]（PHA）、聚[α,β-(N-羟基-N-甲基-DL-天冬酰胺)]（PMHA）和聚[α,β-(N-羟基)-DL-天冬酰胺]/聚[α,β-(N-2-羟乙基)-DL-天冬酰胺]（PHA-PHEA 1:1），并对其抗菌活性进行了筛选。测试中使用了10种革兰氏阳性菌和7种革兰氏阴性菌、5种念珠菌、4种皮肤癣菌和3种霉菌。该化合物对任何测试微生物均无抗菌活性。其他化合物显示出窄谱抗菌活性，但无抗真菌活性。
