作为抗菌剂的藜芦酸衍生物的汉斯ch分析。（注：这里Hansch可能是特定术语，原文拼写可能有误，正常可能是“Hammett analysis”之类，不过按要求准确翻译就是这样）

Hansch analysis of veratric acid derivatives as antimicrobial agents.

作者信息

Narasimhan Balasubramanian, Ohlan Sucheta, Ohlan Ruchita, Judge Vikramjeet, Narang Rakesh

机构信息

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India.

出版信息

Eur J Med Chem. 2009 Feb;44(2):689-700. doi: 10.1016/j.ejmech.2008.05.008. Epub 2008 May 22.

DOI:10.1016/j.ejmech.2008.05.008

PMID:18597896

Abstract

The synthesis, characterization and antimicrobial evaluation of a new series of veratric acid derivatives are presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including Gram-positive and Gram-negative bacteria and fungi. Some of the veratric acid derivatives exhibited significant in vitro antimicrobial activity. QSAR investigation applied to find a correlation between different physicochemical parameters of the veratric acid derivatives and their antimicrobial activity indicated the importance of topological parameters in describing the antimicrobial activity.

摘要

本文介绍了一系列新的藜芦酸衍生物的合成、表征及抗菌活性评价。对标题化合物针对包括革兰氏阳性菌、革兰氏阴性菌和真菌在内的一组微生物进行了初步体外抗菌活性评估。一些藜芦酸衍生物表现出显著的体外抗菌活性。应用定量构效关系（QSAR）研究以找出藜芦酸衍生物不同理化参数与其抗菌活性之间的相关性，结果表明拓扑参数在描述抗菌活性方面具有重要性。