Lanyi Janos K
Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA.
Biochim Biophys Acta. 2006 Aug;1757(8):1012-8. doi: 10.1016/j.bbabio.2005.11.003. Epub 2005 Dec 9.
The steps in the mechanism of proton transport in bacteriorhodopsin include examples for most kinds of proton transfer reactions that might occur in a transmembrane pump: proton transfer via a bridging water molecule, coupled protonation/deprotonation of two buried groups separated by a considerable distance, long-range proton migration over a hydrogen-bonded aqueous chain, and capture as well as release of protons at the membrane-water interface. The conceptual and technical advantages of this system have allowed close examination of many of these model reactions, some at an atomic level.
通过桥连水分子进行质子转移、两个被相当距离隔开的埋藏基团的耦合质子化/去质子化、通过氢键连接的水链进行长程质子迁移以及在膜 - 水界面处捕获和释放质子。该系统在概念和技术上的优势使得能够对许多这些模型反应进行仔细研究，其中一些是在原子水平上进行的。
