Paganelli Maria Ondina, Tanus-Santos José Eduardo, Sabha Maricene, do Prado Joaquim Francisco, Chaud Marco Vinicíus, Martins Luís Cláudio, Moreno Heitor
Cardiovascular Pharmacology and Hypertension Division, Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), SP, Brazil.
Eur J Pharmacol. 2006 Jan 13;530(1-2):124-7. doi: 10.1016/j.ejphar.2005.11.019. Epub 2005 Dec 27.
Bupropion is a non-nicotinic drug used in smoking cessation therapy. However, its acute effects remain unclear. In this study, we investigated the effects of bupropion on hemodynamic parameters in pentobarbital-anesthetized mongrel dogs. Bupropion administered either in bolus injections (3 or 6 mg/kg, i.v.) or in cumulative doses of 0.01, 0.1, 1, 3 and 10 mg/kg showed, in both studies, a significant increase of mean pulmonary arterial pressure and pulmonary vascular resistance index. These results show that bupropion can elevate the pulmonary pressure. Further investigations should be done to test this effect in smokers with chronic obstructive pulmonary disease.
安非他酮是一种用于戒烟治疗的非尼古丁类药物。然而，其急性效应仍不明确。在本研究中，我们调查了安非他酮对戊巴比妥麻醉的杂种犬血流动力学参数的影响。在两项研究中，无论是静脉推注（3或6毫克/千克）还是累积剂量为0.01、0.1、1、3和10毫克/千克给药的安非他酮，均显示平均肺动脉压和肺血管阻力指数显著升高。这些结果表明，安非他酮可升高肺压。应进一步开展研究以在慢性阻塞性肺疾病吸烟者中测试这种效应。
