银屑病患者的吸烟习惯：一项病例对照研究。

Smoking habits in psoriasis: a case control study.

作者信息

Mills C M, Srivastava E D, Harvey I M, Swift G L, Newcombe R G, Holt P J, Rhodes J

机构信息

Department of Gastroenterology, University Hospital of Wales, Cardiff, U.K.

出版信息

Br J Dermatol. 1992 Jul;127(1):18-21. doi: 10.1111/j.1365-2133.1992.tb14818.x.

DOI:10.1111/j.1365-2133.1992.tb14818.x

PMID:1637689

Abstract

We have examined smoking habits in 108 patients with psoriasis, including some with palmoplantar distribution, and compared the results with matched controls from the community. There was a significant association between psoriasis, current smoking status (OR = 2.7, 95% CI 1.44-5.42, P less than 0.01) and smoking habits prior to the onset of disease (OR = 3.75, 95% CI 1.68-9.47, P less than 0.001). There was also a marked dose-response relationship; the relative risk of psoriasis in those currently smoking more than 20 cigarettes/day was significantly elevated (OR = 5.3, 95% CI 2.1-13.0, P less than 0.001). Separate analysis of patients without palmoplantar distribution of psoriasis showed a significant association with smoking prior to onset of psoriasis (OR = 3.6, 95% CI 1.5-9.8, P less than 0.001). Smoking may play a role in the aetiology of this common skin disorder.

摘要

我们对108例银屑病患者的吸烟习惯进行了研究，其中包括一些掌跖部受累的患者，并将结果与来自社区的匹配对照进行了比较。银屑病、当前吸烟状况（比值比=2.7，95%可信区间1.44 - 5.42，P<0.01）以及疾病发作前的吸烟习惯（比值比=3.75，95%可信区间1.68 - 9.47，P<0.001）之间存在显著关联。同时还存在明显的剂量反应关系；目前每天吸烟超过20支的患者患银屑病的相对风险显著升高（比值比=5.3，95%可信区间2.1 - 13.0，P<0.001）。对掌跖部未受累的银屑病患者进行单独分析显示，银屑病发作前吸烟与之存在显著关联（比值比=3.6，95%可信区间1.5 - 9.8，P<0.001）。吸烟可能在这种常见皮肤病的病因中起作用。