Prasad G V Ramesh, Vincent Lloyd, Hamilton Robert, Lim Ki
Division of Nephrology, Department of Medicine, St Michael's Hospital, University of Toronto, Ontario, Canada.
Am J Kidney Dis. 2006 Jan;47(1):e15-6. doi: 10.1053/j.ajkd.2005.09.025.
Numerous agents have been associated with minimal change disease. We describe a previously unreported association in a 45-year-old white woman of scuba diving exposure to fire coral (Millepora species) that was followed by the development of nephrotic syndrome, acute renal failure, pulmonary edema, and intubation. The renal biopsy specimen was consistent with minimal change disease. Institution of corticosteroid therapy resulted in symptomatic improvement and resolution of proteinuria. Physicians, particularly those in scuba-diving areas, should consider minimal change disease in exposed patients with proteinuria because a prompt diagnostic and therapeutic approach may potentially limit complications.
许多因素都与微小病变性肾病有关。我们描述了一例此前未报道过的关联，一名45岁白人女性在潜水时接触了火珊瑚（千孔珊瑚属物种），随后出现了肾病综合征、急性肾衰竭、肺水肿并需要插管。肾活检标本符合微小病变性肾病。使用皮质类固醇治疗后症状改善，蛋白尿消失。医生，尤其是在潜水区域工作的医生，对于出现蛋白尿的暴露患者应考虑微小病变性肾病，因为及时的诊断和治疗方法可能会潜在地限制并发症。
