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丙戊酸钠和氯硝西泮用于治疗难治性惊恐障碍。

Sodium valproate and clonazepam for treatment-resistant panic disorder.

作者信息

Ontiveros A, Fontaine R

机构信息

University Hospital, Monterrey, Mexico.

出版信息

J Psychiatry Neurosci. 1992 Jun;17(2):78-80.

PMID:1637803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1188405/
Abstract

Sodium valproate (VA) and clonazepam (CLZ) were combined in the treatment of 4 patients with panic disorders (PD) who were resistant to several antipanic drug treatments. A significant improvement was found in the symptomatology of these patients, but relapses occurred when CLZ dosage was reduced. A potentiation of the GABAergic properties of VA and clonazepam is postulated. This combined treatment could be advantageous for some treatment-resistant PD patients but needs to be studied further.

摘要

丙戊酸钠（VA）和氯硝西泮（CLZ）联合用于治疗4例对多种抗惊恐药物治疗无效的惊恐障碍（PD）患者。这些患者的症状有显著改善，但当氯硝西泮剂量减少时会复发。推测丙戊酸钠和氯硝西泮的GABA能特性增强。这种联合治疗对一些难治性惊恐障碍患者可能有益，但需要进一步研究。

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