Primeau F, Fontaine R, Beauclair L
Royal Victoria Hospital, Montreal, Quebec.
Can J Psychiatry. 1990 Apr;35(3):248-50. doi: 10.1177/070674379003500309.
Valproic acid (VA), an anticonvulsant which increases GABAergic transmission was given to patients suffering from recurrent panic attacks. Ten consecutive outpatients were included in this study. After a seven day placebo washout period, patients were given a dose of 500 mg/day, which was gradually increased to a maximum of 2250 mg/day. A significant improvement was found in the symptomatology of patients as measured on the Clinical Global Impression Scale for panic severity (p less than 0.001), the Hamilton Psychiatric Rating Scale for Anxiety (p less than 0.001) and the panic factor of the SCL-90 (p less than 0.05). These findings support the hypothesis that VA is useful in the treatment of panic disorders. Further research should be carried out to assess its efficacy and safety.
丙戊酸（VA）是一种能增强γ-氨基丁酸（GABA）能传递的抗惊厥药，被用于治疗复发性惊恐发作的患者。本研究纳入了连续10名门诊患者。在为期7天的安慰剂洗脱期后，给予患者500毫克/天的剂量，并逐渐增加至最大剂量2250毫克/天。根据惊恐严重程度临床总体印象量表（p<0.001）、汉密尔顿焦虑量表（p<0.001）和症状自评量表90项（SCL-90）中的惊恐因子（p<0.05）测量发现，患者的症状有显著改善。这些发现支持了VA对治疗惊恐障碍有用的假说。应开展进一步研究以评估其疗效和安全性。
