Xu Xiaoming, Ling Long, Wang Rubin, Burgess John O
Department of Operative Dentistry and Biomaterials, Louisiana State University Health Sciences Center, School of Dentistry, 1100 Florida Avenue, New Orleans, LA 70119, USA.
Dent Mater. 2006 Nov;22(11):1014-23. doi: 10.1016/j.dental.2005.11.027. Epub 2005 Dec 27.
The aims of this study were to formulate a novel fluoride-releasing dental composite and to evaluate its mechanical properties, fluoride release and recharge capabilities, water sorption and solubility.
A fluoride-releasing dimethacrylate monomer containing a ternary zirconium fluoride chelate was synthesized. Three experimental fluoride-releasing composites were fabricated with different monomer formulas (wt.%)-(1) Control A: 40 BisGMA/40 TEDMA/20 UEDMA; (2) EXPERIMENTAL: 20 F-releasing monomer/20 BisGMA/40 TEDMA/20 UEDMA; (3) Control B: the same formula as Control A except that it contained 10 wt.% (of total monomer) tetrabutylammonium fluoride (TBAF), which had a fluoride content equivalent to EXPERIMENTAL. All three materials had the same filler content: 55 wt.% silanized fluoroaluminosilicate particles (0.8 microm) and 10 wt.% silanized fumed silica (14 nm). All materials contained 0.17 wt.% camphorquinone (CQ) as a photoinitiator and 0.69 wt.% ethyl-4-dimethylaminobenzoate (4EDMAB) as an accelerator. The materials were tested for fluoride release (for 184 days), fluoride recharge, compressive and flexure strength, water sorption and solubility. The data were analyzed using ANOVA and Tukey-HSD tests, and Kruskal-Wallis test.
The experimental composite had significantly higher fluoride release and fluoride recharge capabilities than both Control composites. It had significantly better physical and mechanical properties than Control B.
The combined use of the fluoride-releasing dimethacrylate monomer and fluoride-releasing filler can provide sustained high fluoride release and recharge as well as acceptable mechanical and physical properties. Simply adding organic fluoride salt in the monomer yields composites with poor mechanical and physical properties.
本研究的目的是制备一种新型的释氟牙科复合材料，并评估其机械性能、氟释放和再充注能力、吸水性和溶解性。
合成了一种含三元氟化锆螯合物的释氟二甲基丙烯酸酯单体。用不同的单体配方（重量百分比）制备了三种实验性释氟复合材料：(1) 对照A：40%双酚A双甲基丙烯酸缩水甘油酯（BisGMA）/40%三乙二醇二甲基丙烯酸酯（TEDMA）/20%脲烷二甲基丙烯酸酯（UEDMA）；(2) 实验组：20%释氟单体/20% BisGMA/40% TEDMA/20% UEDMA；(3) 对照B：与对照A配方相同，但含有10%（占总单体的重量）的四丁基氟化铵（TBAF），其氟含量与实验组相当。所有三种材料的填料含量相同：55%（重量）硅烷化氟铝硅酸盐颗粒（0.8微米）和10%（重量）硅烷化气相二氧化硅（14纳米）。所有材料均含有0.17%（重量）的樟脑醌（CQ）作为光引发剂和0.69%（重量）的4-二甲基氨基苯甲酸乙酯（4EDMAB）作为促进剂。对材料进行氟释放（184天）、氟再充注、压缩强度和弯曲强度、吸水性和溶解性测试。使用方差分析和Tukey-HSD检验以及Kruskal-Wallis检验对数据进行分析。
实验复合材料的氟释放和氟再充注能力明显高于两种对照复合材料。其物理和机械性能明显优于对照B。
释氟二甲基丙烯酸酯单体和释氟填料的联合使用可以提供持续的高氟释放和再充注以及可接受的机械和物理性能。简单地在单体中添加有机氟盐会得到机械和物理性能较差的复合材料。
