Voronin L A
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region.
Biochimie. 1992 May;74(5):491-4. doi: 10.1016/0300-9084(92)90090-2.
Q beta replicase replicates a variety of enzyme-specific small RNAs in addition to the phage genomic RNA. The sequence analysis has revealed that all these RNAs are potentially capable of forming a consensus secondary structure element. It represents a stalk which is formed by the 5'-GGG ... and ... CCCA-3' complementary stretches at the termini of the replicating RNA molecules and adjacent 5'- and 3'-hairpins, which may form a stacking with the stalk. The structure found is rather similar to the analogous structure in the tRNA molecule. The genomic RNA of the Q beta phage and other related phages can also form a similar structural element.
Qβ复制酶除了能复制噬菌体基因组RNA外，还能复制多种酶特异性小RNA。序列分析表明，所有这些RNA都有可能形成一个共有二级结构元件。它代表一个茎干，由复制RNA分子末端的5'-GGG...和...CCCA-3'互补序列以及相邻的5'-和3'-发夹结构组成，这些发夹结构可能与茎干形成堆积。所发现的结构与tRNA分子中的类似结构相当相似。Qβ噬菌体和其他相关噬菌体的基因组RNA也能形成类似的结构元件。
