奥卡西平和卡马西平所致低钠血症

Hyponatremia from oxcarbazepine and carbamazepine.

作者信息

Dong Xiaoming, Leppik Ilo E, White James, Rarick John

机构信息

Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Neurology. 2005 Dec 27;65(12):1976-8. doi: 10.1212/01.wnl.0000188819.45330.90.

DOI:10.1212/01.wnl.0000188819.45330.90

PMID:16380624

Abstract

The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies. The frequency of hyponatremia (Na+ < or = 134 mEq/L) was 29.9% among OXC-treated patients and 13.5% among CBZ-treated patients (p < 0.0001). Hyponatremia (Na+ < or = 128 mEq/L) was severe: 12.4% of OXC-treated patients and 2.8% of CBZ-treated patients (p < 0.001). Advanced age was a risk factor for hyponatremia. Hyponatremia, once present, persisted in both groups.

摘要

作者通过横断面研究和随访研究，检测了97例接受奥卡西平（OXC）治疗的癫痫患者和451例接受卡马西平（CBZ）治疗的癫痫患者的血钠浓度。奥卡西平治疗组低钠血症（血钠浓度≤134 mEq/L）的发生率为29.9%，卡马西平治疗组为13.5%（p<0.0001）。严重低钠血症（血钠浓度≤128 mEq/L）的发生率为：奥卡西平治疗组12.4%，卡马西平治疗组2.8%（p<0.001）。高龄是低钠血症的一个危险因素。低钠血症一旦出现，在两组中都会持续存在。