McConnell S K
Department of Biological Sciences, Stanford University, California 94305.
Curr Opin Neurobiol. 1992 Feb;2(1):23-7. doi: 10.1016/0959-4388(92)90156-f.
Recent studies of the lineages and developmental potential of cortical neurons show that cell fates are progressively restricted during cerebral cortical development. Cell lineage experiments suggest that individual cortical precursors are multipotent, as their progeny can end up in different cortical areas, and in different layers within an area. Transplantation studies have shown that young neurons are committed very early on to adopting a given laminar position, in a manner correlated with their birth date in the ventricular zone. Neurons in different neocortical areas, however, retain a functional and anatomical equipotentiality well into cortical development, suggesting that positional cues determine a cell's area-specific identity.
近期对皮质神经元谱系和发育潜能的研究表明，在大脑皮质发育过程中细胞命运逐渐受到限制。细胞谱系实验表明，单个皮质前体细胞具有多能性，因为它们的后代最终可分布于不同的皮质区域以及同一区域的不同层中。移植研究表明，年轻神经元在早期就确定会采用特定的层状位置，其方式与它们在脑室区的出生日期相关。然而，不同新皮质区域的神经元在皮质发育的很长一段时间内仍保持功能和解剖学上的等潜能性，这表明位置线索决定了细胞的区域特异性身份。
