Catterall William A, Goldin Alan L, Waxman Stephen G
Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195-7280.
Pharmacol Rev. 2005 Dec;57(4):397-409. doi: 10.1124/pr.57.4.4.
The family of voltage-gated sodium channels initiates action potentials in all types of excitable cells. Nine members of the voltage-gated sodium channel family have been characterized in mammals, and a 10th member has been recognized as a related protein. These distinct sodium channels have similar structural and functional properties, but they initiate action potentials in different cell types and have distinct regulatory and pharmacological properties. This article presents the molecular relationships and physiological roles of these sodium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties.
电压门控钠通道家族在所有类型的可兴奋细胞中引发动作电位。在哺乳动物中，已对电压门控钠通道家族的九个成员进行了表征，并且第十个成员已被确认为一种相关蛋白。这些不同的钠通道具有相似的结构和功能特性，但它们在不同类型的细胞中引发动作电位，并且具有不同的调节和药理特性。本文介绍了这些钠通道蛋白的分子关系和生理作用，并提供了有关其分子、遗传、生理和药理特性的全面信息。
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