小鼠Akp1基因座的一个新变体。

A new variant of the mouse Akp1 locus.

作者信息

Lee Chul-Ho, Kim Eun-Hee, Won Young-Suk, Choi Yang-Kyu, Nam Ki-Hoan, Kim Hyoung-Chin, Hyun Byung-Hwa, Suh Jun-Gyo, Oh Yang-Seok

机构信息

ICLAS Monitoring Subcenter Korea, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, Korea.

出版信息

Biochem Genet. 2005 Dec;43(11-12):597-602. doi: 10.1007/s10528-005-9116-5.

DOI:10.1007/s10528-005-9116-5

PMID:16382364

Abstract

A new electrophoretic migration type of alkaline phosphatase 1 (Akp1) was found on the cellulose acetate electrophoresis for kidney and liver homogenates of KWHM mouse, a newly established inbred strain derived from the Korean wild mouse (Mus musculus molossinus). This new type of alkaline phosphatase 1 was distinguished from previously reported AKP1A and AKP1B types in the mouse, and tentatively named AKP1C. In genetic analysis by mating experiments between KWHM and C57BL/6J (AKP1A) or BALB/cA (AKP1B), the phenotypic segregation ratios of AKP1A : AKP1AC : AKP1C or AKP1B : AKP1BC : AKP1C were 1 : 2 : 1 in both groups of F2 generations. It was therefore concluded that AKP1C type is controlled by Akp1c allele which is codominant with Akp1a and Akp1b alleles.

摘要

在一种新建立的源自韩国野生小鼠（小家鼠）的近交系KWHM小鼠的肾脏和肝脏匀浆的醋酸纤维素电泳中，发现了一种碱性磷酸酶1（Akp1）的新电泳迁移类型。这种新型碱性磷酸酶1与小鼠中先前报道的AKP1A和AKP1B类型不同，暂命名为AKP1C。在通过KWHM与C57BL/6J（AKP1A）或BALB/cA（AKP1B）进行交配实验的遗传分析中，F2代两组中AKP1A : AKP1AC : AKP1C或AKP1B : AKP1BC : AKP1C的表型分离比均为1 : 2 : 1。因此得出结论，AKP1C类型由Akp1c等位基因控制，该等位基因与Akp1a和Akp1b等位基因共显性。