家鼠（小家鼠）碱性磷酸酶的遗传变异，重点关注一种需要锰的同工酶。
Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme.
作者信息
Wilcox F H, Hirschhorn L, Taylor B A, Womack J E, Roderick T H
出版信息
Biochem Genet. 1979 Dec;17(11-12):1093-107. doi: 10.1007/BF00504347.
Genetic variation among inbred strains is described for electrophoretic migration of alkaline phosphatase from intestine, kidney, blood plasma, and three isozymes of liver. A manganese-requiring isozyme of liver and kidney unaffected by neuraminidase is described, and the locus controlling variation in this isozyme is designated Akp-1. Data from recombinant inbred strains place the locus on chromosome 1 at a distance of 3.6 +/- 2.9 cM from the M1s locus on the side distal to the centromere. Test-cross data show the following gene order and recombination percentages: Dip-1 19.0 +/- 3.8% Lp 7.4 +/- 2.2% Akp-1.
描述了近交系之间碱性磷酸酶在肠道、肾脏、血浆中的电泳迁移以及肝脏三种同工酶的遗传变异。描述了一种不受神经氨酸酶影响的肝脏和肾脏需要锰的同工酶，控制该同工酶变异的基因座命名为Akp - 1。重组近交系的数据将该基因座定位在1号染色体上，距着丝粒远端的M1s基因座3.6 +/- 2.9厘摩处。测交数据显示以下基因顺序和重组率：Dip - 1 19.0 +/- 3.8%，Lp 7.4 +/- 2.2%，Akp - 1。
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