Chick J, Gough K, Falkowski W, Kershaw P, Hore B, Mehta B, Ritson B, Ropner R, Torley D
Department of Psychiatry, Edinburgh University, Royal Edinburgh Hospital.
Br J Psychiatry. 1992 Jul;161:84-9. doi: 10.1192/bjp.161.1.84.
To assess the efficacy of supervised disulfiram as an adjunct to out-patient treatment of alcoholics, a randomised, partially blind, six-month follow-up study was conducted in which 126 patients received 200 mg disulfiram or 100 mg vitamin C under the supervision of a nominated informant. In the opinion of the (blinded) independent assessor, patients on disulfiram increased average total abstinent days by 100 and patients on vitamin C by 69, thus enhancing by one-third this measure of treatment outcome. Mean weekly alcohol consumption was reduced by 162 units with disulfiram, compared with 105 units with vitamin C, and the disulfiram patients reduced their total six-month alcohol consumption by 2572 units compared with an average reduction of 1448 units in the vitamin C group. Serum gamma-GT showed a mean fall of 21 IU/I in patients on disulfiram but rose by a mean of 13 IU/I with vitamin C. Unwanted effects in the disulfiram group led to a dose reduction in seven patients and to treatment withdrawal in four (and in one vitamin C patient). Two-thirds of the disulfiram group asked to continue the treatment at the end of the study. There were no medically serious adverse reactions.
为评估监督下服用双硫仑作为门诊治疗酗酒者辅助手段的疗效，开展了一项随机、部分盲法、为期六个月的随访研究，126名患者在指定告知者的监督下服用200毫克双硫仑或100毫克维生素C。据（盲法）独立评估者判断，服用双硫仑的患者平均完全戒酒天数增加了100天，服用维生素C的患者增加了69天，从而使这一治疗效果指标提高了三分之一。与服用维生素C的患者每周平均饮酒量减少105单位相比，服用双硫仑的患者每周平均饮酒量减少了162单位，且服用双硫仑的患者六个月的总饮酒量减少了2572单位，而维生素C组平均减少了1448单位。服用双硫仑的患者血清γ-谷氨酰转移酶平均下降21 IU/I，而服用维生素C的患者平均上升13 IU/I。双硫仑组的不良反应导致7名患者减少剂量，4名患者停药（维生素C组有1名患者停药）。研究结束时，三分之二的双硫仑组患者要求继续治疗。未出现严重的医学不良反应。
