Garber M R, Pleskach V G, Meshkova L I
Probl Endokrinol (Mosk). 1988 Mar-Apr;34(2):32-4.
Disulfiram is one of the most common agents used for the treatment of alcoholism. A study was made of disulfiram influence on the level of testosterone and spermiogenesis in 20 alcoholic patients during course therapy. The level of testosterone was investigated before treatment and 15 and 30 days after treatment with disulfiram at a daily dose of 0.5 g. Sixteen patients of the control group received tranquilizers. Ejaculation specimens were studied before treatment and 30 days after the onset of a therapeutic course. Disulfiram therapy was shown to cause the reduction of the level of testosterone as compared to its basal level and deterioration of spermiogenesis indices as compared to the controls receiving tranquilizers. It should be borne in mind during prolonged therapeutic courses.
双硫仑是治疗酒精中毒最常用的药物之一。对20例酒精中毒患者在疗程治疗期间双硫仑对睾酮水平和精子发生的影响进行了研究。在治疗前以及每日服用0.5 g双硫仑治疗15天和30天后，对睾酮水平进行了调查。对照组的16名患者服用了镇静剂。在治疗前和疗程开始30天后对射精标本进行了研究。结果表明，与基础水平相比，双硫仑治疗导致睾酮水平降低，与服用镇静剂的对照组相比，精子发生指标恶化。在长期治疗过程中应予以注意。
