Hoozemans J J M, Veerhuis R, Rozemuller J M, Eikelenboom P
Department of Neuropathology, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 110DE Amsterdam, The Netherlands.
Int J Dev Neurosci. 2006 Apr-May;24(2-3):157-65. doi: 10.1016/j.ijdevneu.2005.11.001. Epub 2005 Dec 27.
The initial stages of Alzheimer's disease pathology in the neocortex show upregulation of cell cycle proteins, adhesion and inflammation related factors, indicating the early involvement of inflammatory and regenerating pathways in Alzheimer's disease pathogenesis. These brain changes precede the neurofibrillary pathology and the extensive process of neurodestruction and (astro)gliosis. Amyloid beta deposition, inflammation and regenerative mechanisms are also early pathogenic events in transgenic mouse models harbouring the pathological Alzheimer's disease mutations, while neurodegenerative characteristics are not seen in these models. This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis.
阿尔茨海默病新皮质病理的初始阶段表现为细胞周期蛋白、黏附及炎症相关因子的上调，这表明炎症和再生途径在阿尔茨海默病发病机制中早期即有参与。这些脑部变化先于神经纤维病理改变以及神经破坏和（星形）胶质增生的广泛过程。淀粉样β沉积、炎症和再生机制也是携带阿尔茨海默病病理突变的转基因小鼠模型中的早期致病事件，而这些模型中未见神经退行性特征。本综述将讨论阿尔茨海默病发病机制早期神经炎症与神经再生之间的关系。
