雌二醇对垂体肿瘤和细胞生长的调控与激肽释放酶基因表达的调控不相关。

The control by estradiol of pituitary tumor and cell growth is not correlated with that of kallikrein gene expression.

作者信息

Faurobert E, Albaladéjo V, Joly-Pharaboz M O, Girolami J P, André J

机构信息

INSERM--U 329, Hôpital Debrousse, Lyon, France.

出版信息

Cancer Lett. 1992 Jul 10;64(3):211-8. doi: 10.1016/0304-3835(92)90045-w.

DOI:10.1016/0304-3835(92)90045-w

PMID:1638513

Abstract

From an MtTF4 pituitary tumor we established new cell lines and tumors whose growth is sensitive (stimulation or inhibition) or insensitive to estradiol (Cancer Res., 1991, 50, 3786-3794). The main objective of the present work was to determine whether such a diversity of responses is correlated with the estradiol control of kallikrein gene expression. From kallikrein mRNA analyses and from kallikrein activity assays in conditioned medium it appears highly probable that the diversity of responses to estradiol of pituitary tumors and cell growth is not due to a differential regulation of kallikrein gene expression. In addition, prolactin gene expression and estrogen receptor mRNA have been studied to further characterize this experimental model.

摘要

我们从一例MtTF4垂体瘤中建立了新的细胞系和肿瘤，其生长对雌二醇敏感（刺激或抑制）或不敏感（《癌症研究》，1991年，50卷，3786 - 3794页）。本研究的主要目的是确定这种反应多样性是否与激肽释放酶基因表达的雌二醇调控相关。从激肽释放酶mRNA分析以及条件培养基中的激肽释放酶活性测定来看，垂体瘤对雌二醇的反应多样性和细胞生长很可能并非由于激肽释放酶基因表达的差异调控。此外，还研究了催乳素基因表达和雌激素受体mRNA，以进一步表征该实验模型。