Kwak L W, Campbell M J, Levy R
Department of Medicine, Stanford University Medical School, California 94305-5306.
Cancer Res. 1992 Aug 1;52(15):4117-20.
Lethally irradiated C3H/HeN mice reconstituted with normal syngeneic bone marrow survived significantly longer than unmanipulated control mice following challenge with a lethal dose of 38C13 lymphoma cells 2 to 3 weeks post-bone marrow transplantation (BMT). Although the magnitude of this effect was modest, it was highly reproducible. This resistance-producing effect of BMT could be enhanced by interleukin 2 administration and could be abrogated by anti-asialo-GM1 antiserum treatment of recipients. These findings are consistent with the hypothesis that cells with a natural killer phenotype are activated by BMT and can mediate tumor resistance. These studies provide a model to explore the cellular basis, independent of donor alloreactivity, of the graft antitumor effect of BMT observed in humans.
用正常同基因骨髓重建的经致死剂量照射的C3H/HeN小鼠，在骨髓移植（BMT）后2至3周接受致死剂量的38C13淋巴瘤细胞攻击后，存活时间明显长于未处理的对照小鼠。尽管这种效应的程度不大，但具有高度可重复性。BMT的这种产生抗性的效应可通过给予白细胞介素2来增强，并可通过对受体进行抗唾液酸GM1抗血清治疗而消除。这些发现与以下假设一致，即具有自然杀伤表型的细胞被BMT激活，并可介导肿瘤抗性。这些研究提供了一个模型，以探索在人类中观察到的BMT移植物抗肿瘤效应的细胞基础，而不依赖于供体同种异体反应性。
