Rimdeika Rytis, Gudaviciene Daiva, Adamonis Kestutis, Barauskas Giedrius, Pavalkis Dainius, Endzinas Zilvinas
Kaunas University of Medicine, Department of Plastic Surgery and Burns, Eiveniu 2, Kaunas, Lithuania.
Burns. 2006 Feb;32(1):83-6. doi: 10.1016/j.burns.2005.08.003. Epub 2005 Dec 28.
Enteral nutrition as an important component of modern treatment is mandatory for patients suffering from major burns. Regardless of the initial estimation of caloric requirements, actual daily volume of energy consumption may vary depending on the general condition of the patient and the side effects of enteral nutrition. The aim of our study was to investigate the relation between caloric value of enteral nutrition and treatment course.
The prospective study involved 103 adult patients treated in the Hospital of Kaunas University of Medicine for 2 degrees -3 degrees burns of 10-80% body surface area from 1 January 2001 till 31 December 2003. All patients received enteral nutrition during the acute phase. After the completion of the treatment, caloric value of enteral nutrition was estimated, and patients were divided into two groups: group A received more than 30 kcal/(kg 24 h); and group B, received less than 30 kcal/(kg 24 h). We compared patients' mortality, complication rate, and hospital stay time.
The mortality of patients, who enterally received less than 30 kcal/(kg 24 h), was 32.6%, comparing to 5.3% mortality in patients who received 30 or more kcal/(kg 24 h) (p < 0.01). The caloric value of less than 30 kcal/(kg 24 h) increased the frequency of pneumonia by 2.0 times, and the frequency of sepsis by 1.8 times (p < 0.05). The duration of the treatment of survivors in this group was by 12.6 days longer (p = 0.01).
The caloric value of enteral nutrition seems to be associated with patient mortality, complication rate, and treatment duration. The results of the treatment of patients who received more or 30 kcal/(kg 24 h) were much better. Because determined relationship may not be directly causal, further study is needed to determine whether active intervention to improve nutrition could improve outcomes.
肠内营养作为现代治疗的重要组成部分,对于重度烧伤患者来说是必不可少的。无论最初对热量需求的估计如何,实际每日能量消耗的量可能会因患者的一般状况和肠内营养的副作用而有所不同。我们研究的目的是调查肠内营养的热量值与治疗过程之间的关系。
这项前瞻性研究纳入了2001年1月1日至2003年12月31日期间在考纳斯医科大学医院接受治疗的103例成年患者,他们的烧伤面积为体表面积的10%-80%,烧伤程度为二度至三度。所有患者在急性期均接受肠内营养。治疗结束后,估计肠内营养的热量值,并将患者分为两组:A组接受的热量超过30千卡/(千克·24小时);B组接受的热量低于30千卡/(千克·24小时)。我们比较了患者的死亡率、并发症发生率和住院时间。
肠内接受热量低于30千卡/(千克·24小时)的患者死亡率为32.6%,而接受30千卡/(千克·24小时)或更多热量的患者死亡率为5.3%(p<0.01)。热量低于30千卡/(千克·24小时)使肺炎的发生率增加了2.0倍,败血症的发生率增加了1.8倍(p<0.05)。该组幸存者的治疗时间延长了12.6天(p=0.01)。
肠内营养的热量值似乎与患者死亡率、并发症发生率和治疗持续时间有关。接受30千卡/(千克·24小时)或更多热量的患者治疗效果要好得多。由于所确定的关系可能不是直接因果关系,需要进一步研究以确定积极干预改善营养是否能改善治疗结果。