Preble O T, Youngner J S
J Infect Dis. 1975 Apr;131(4):467-73. doi: 10.1093/infdis/131.4.467.
Several mechanisms have been put forward to explain how persistently infected virus-carrier cell cultures are maintained. In this report, information is summarized which suggests that selection of temperature-sensitive mutants may be involved in either establishment or maintenance of persistent infections both in cell cultures and in animals. The possible relation of this mechanism to other mechanisms of regulation of persistent infections is also discussed. Finally, a practical suggestion is offered to researchers and clinicians seeking endogenous viruses from cultured cells and tissues that may harbor temperature-sensitive variants.
已经提出了几种机制来解释持续感染的病毒载体细胞培养物是如何维持的。在本报告中，总结了一些信息，这些信息表明温度敏感突变体的选择可能参与细胞培养物和动物中持续性感染的建立或维持。还讨论了这种机制与持续性感染的其他调节机制之间的可能关系。最后，针对从可能含有温度敏感变体的培养细胞和组织中寻找内源性病毒的研究人员和临床医生，提供了一条实用建议。
