Persson Ingrid A-L, Dong Linda, Persson Karin
Department of Medicine and Care, Division of Pharmacology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
J Ethnopharmacol. 2006 May 24;105(3):321-5. doi: 10.1016/j.jep.2005.10.030. Epub 2006 Jan 4.
This study investigates the effects of the Panax ginseng (Araliaceae) extract G115 on angiotensin-converting enzyme (ACE) activity and nitric oxide (NO) in cultured human endothelial cells from umbilical veins (HUVEC) and bovine mesenteric arteries (BMA). In HUVEC, ACE activity was significantly reduced after 10 min incubation with aqueous extract of ginseng 5.0 and 10 mg/ml. This effect was additative with the inhibition of the traditional ACE inhibitor enalaprilat. No effect was seen on NO production from the cells. Angiotensin I-induced contraction of BMA was significantly attenuated by 0.1 and 0.5 mg/ml ginseng, while no endothelium-dependent or -independent relaxation was seen. In conclusion, extract of Panax ginseng (G115) inhibits ACE activity, but does not affect NO production in HUVEC and BMA.
本研究调查了人参（五加科）提取物G115对人脐静脉内皮细胞（HUVEC）和牛肠系膜动脉（BMA）中血管紧张素转换酶（ACE）活性及一氧化氮（NO）的影响。在HUVEC中，与5.0和10 mg/ml人参水提取物孵育10分钟后，ACE活性显著降低。这种作用与传统ACE抑制剂依那普利拉的抑制作用相加。对细胞产生NO未见影响。0.1和0.5 mg/ml人参可显著减弱血管紧张素I诱导的BMA收缩，而未见内皮依赖性或非依赖性舒张。总之，人参提取物（G115）抑制ACE活性，但不影响HUVEC和BMA中NO的产生。
