微管稳定剂的双重作用：双皮质素样激酶和双皮质素在发育中的大脑皮层中的协同功能。

Doubling up on microtubule stabilizers: synergistic functions of doublecortin-like kinase and doublecortin in the developing cerebral cortex.

作者信息

Weimer Jill M, Anton E S

机构信息

Neuroscience Center, Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

出版信息

Neuron. 2006 Jan 5;49(1):3-4. doi: 10.1016/j.neuron.2005.12.016.

DOI:10.1016/j.neuron.2005.12.016

PMID:16387632

Abstract

Dynamic regulation of neuronal cytoskeletal machinery in response to extracellular cues enables distinct changes in neuronal development in the cerebral cortex. In this issue of Neuron, three related studies on doublecortin-like kinase, a microtubule-associated protein related to doublecortin, by Shu et al., Koizumi et al., and Deuel et al., provide evidence that doublecortin-like kinase is essential for proper neurogenesis, neuronal migration, and axonal wiring.

摘要

神经元细胞骨架机制对细胞外信号的动态调节，使得大脑皮层神经元发育发生显著变化。在本期《神经元》杂志中，Shu等人、Koizumi等人以及Deuel等人发表了三项关于双皮质素样激酶（一种与双皮质素相关的微管相关蛋白）的相关研究，这些研究提供了证据表明双皮质素样激酶对于正常的神经发生、神经元迁移和轴突布线至关重要。