O'Neill Joseph, Senior Timothy, Csicsvari Jozsef
MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, UK.
Neuron. 2006 Jan 5;49(1):143-55. doi: 10.1016/j.neuron.2005.10.037.
We observed sharp wave/ripples (SWR) during exploration within brief (<2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility or sleep were similar. However, neuronal activity during eSWR was location dependent, and eSWR-related firing was stronger inside the place field than outside. The eSPW-related firing increase was stronger than the baseline increase inside compared to outside, suggesting a "supralinear" summation of eSWR and place-selective inputs. Pairs of cells with similar place fields and/or correlated firing during exploration showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential activation of place cells was not required for the reactivation of waking co-firing patterns; cell pairs with symmetrical cross-correlations still showed reactivated waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing during eSWRs facilitates initial associations between cells with similar place fields that enable place-related ensemble patterns to recur during subsequent sleep-SWRs.
我们在探索过程中，于短暂（<2.4秒）的θ振荡中断期间或期间观察到了尖波/涟漪（SWR）。在探索期间出现的SWR（eSWR）的CA1网络反应与在清醒不动或睡眠中检测到的SWR相似。然而，eSWR期间的神经元活动取决于位置，并且与eSWR相关的放电在位置场内比场外更强。与基线相比，场内与eSPW相关的放电增加比场外更强，这表明eSWR和位置选择性输入存在“超线性”总和。在探索期间具有相似位置场和/或相关放电的细胞对在eSWR和随后的睡眠SWR期间显示出更强的共激活。清醒时共同放电模式的重新激活不需要位置细胞的顺序激活；具有对称交叉相关性的细胞对在睡眠SWR期间仍显示出重新激活的清醒共同放电模式。我们认为，eSWR期间的位置选择性放电促进了具有相似位置场的细胞之间的初始关联，从而使与位置相关的整体模式在随后的睡眠SWR期间再次出现。
