Neuroscience Institute and Department of Neurology, NYU Grossman School of Medicine, New York University, New York City, NY, USA.
Center for Neural Science, New York University, New York City, NY, USA.
Science. 2024 Mar 29;383(6690):1478-1483. doi: 10.1126/science.adk8261. Epub 2024 Mar 28.
Experiences need to be tagged during learning for further consolidation. However, neurophysiological mechanisms that select experiences for lasting memory are not known. By combining large-scale neural recordings in mice with dimensionality reduction techniques, we observed that successive maze traversals were tracked by continuously drifting populations of neurons, providing neuronal signatures of both places visited and events encountered. When the brain state changed during reward consumption, sharp wave ripples (SPW-Rs) occurred on some trials, and their specific spike content decoded the trial blocks that surrounded them. During postexperience sleep, SPW-Rs continued to replay those trial blocks that were reactivated most frequently during waking SPW-Rs. Replay content of awake SPW-Rs may thus provide a neurophysiological tagging mechanism to select aspects of experience that are preserved and consolidated for future use.
经验需要在学习过程中进行标记，以进一步巩固。然而，用于选择持久记忆的神经生理机制尚不清楚。通过结合小鼠的大规模神经记录和降维技术，我们观察到连续的迷宫穿越被不断漂移的神经元群体跟踪，为所访问的位置和遇到的事件提供了神经元特征。当大脑状态在奖励消费过程中改变时，在一些试验中会出现尖波涟漪（SPW-R），并且它们的特定尖峰内容解码了它们周围的试验块。在经历后的睡眠中，SPW-R 继续回放那些在清醒 SPW-R 中最频繁被激活的试验块。因此，清醒 SPW-R 的回放内容可能提供了一种神经生理标记机制，用于选择那些被保留和巩固以备将来使用的经验方面。
