通过烯丙基sp3 C-H键与亚甲基sp3 C-H键之间的交叉脱氢偶联反应实现催化烯丙基烷基化。
Catalytic allylic alkylation via the cross-dehydrogenative-coupling reaction between allylic sp3 C-H and methylenic sp3 C-H bonds.
作者信息
Li Zhiping, Li Chao-Jun
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
出版信息
J Am Chem Soc. 2006 Jan 11;128(1):56-7. doi: 10.1021/ja056541b.
PMID:16390119
Abstract
A catalytic allylic alkylation was developed via the cross-dehydrogenative-coupling reaction of allylic sp3 C-H and methylenic sp3 C-H catalyzed by copper bromide and cobalt chloride in the presence of an oxidizing reagent, t-BuOOH. This methodology provides a direct way to use allylic sp3 C-H bonds for forming C-C bonds.
摘要
通过在氧化剂叔丁基过氧化氢存在下，由溴化铜和氯化钴催化烯丙基sp3 C-H与亚甲基sp3 C-H的交叉脱氢偶联反应，开发了一种催化烯丙基烷基化反应。该方法提供了一种直接利用烯丙基sp3 C-H键形成碳-碳键的途径。
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