La Marca Antonio, Carducci Artenisio Alfredo, Stabile Gaspare, Rivasi Francesco, Volpe Annibale
Institute of Obstetrics and Gynecology, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Gynecol Endocrinol. 2005 Dec;21(6):303-6. doi: 10.1080/09513590500402756.
It was the purpose of the present study to investigate whether human endometrium expresses follicle-stimulating hormone (FSH) receptor mRNA and peptide, and whether this expression is regulated in a cycle-dependent manner in endometrium derived from various phases of the menstrual cycle.
FSH receptor mRNA and peptide expression were evaluated by reverse transcription-polymerase chain reaction and by immunohistochemistry in endometrium from 15 women undergoing hysteroscopy to evaluate the morphology of the uterine cavity or hysterectomy for leiomyomas.
FSH receptor mRNA was expressed by human endometrium, and its peptide was located immunohistochemically in both proliferative and secretory endometrial epithelial and stromal cells. A significant increase in immunoreactive FSH receptor was observed during the secretory phase.
We have shown the presence of FSH receptor in human endometrium and demonstrated that FSH receptor immunostaining is upregulated in the secretory phase of the menstrual cycle. The dynamic pattern of receptor expression indicates that FSH may play a role in the regulation of endometrial function and possibly in the embryo-endometrium interaction.
本研究旨在调查人子宫内膜是否表达促卵泡激素（FSH）受体mRNA和肽，以及在月经周期不同阶段的子宫内膜中这种表达是否以周期依赖性方式受到调节。
采用逆转录聚合酶链反应和免疫组织化学方法，对15例因宫腔镜检查评估宫腔形态或因子宫肌瘤行子宫切除术的女性的子宫内膜进行FSH受体mRNA和肽表达评估。
人子宫内膜表达FSH受体mRNA，其肽通过免疫组织化学定位在增殖期和分泌期子宫内膜的上皮细胞和基质细胞中。在分泌期观察到免疫反应性FSH受体显著增加。
我们已证明人子宫内膜中存在FSH受体，并表明在月经周期的分泌期FSH受体免疫染色上调。受体表达的动态模式表明FSH可能在子宫内膜功能调节以及胚胎与子宫内膜相互作用中发挥作用。
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