紫外线照射病毒对水疱性口炎病毒V组温度敏感突变体的非遗传互补作用
Nongenetic complementation of group V temperature-sensitive mutants of vesicular stomatitis virus by UV-irradiated virus.
作者信息
Deutsch V
出版信息
J Virol. 1975 Apr;15(4):798-805. doi: 10.1128/JVI.15.4.798-805.1975.
Abstract
Cells infected with temperature-sensitive (ts) mutants of complementation group V of vesicular stomatitis virus (VSV) give an enhanced yield at nonpermissive temperature when co-infected or superinfected with UV-irradiated virus. Virions produced in these mixed infections are temperature sensitive and do not complement ts V45. Rescue of group V mutants is multiplicity dependent. It can occur in the presence of cycloheximide; kinetics of rescue are similar in the absence or in the presence of the drug. Rescue is due to nongenetic complementation and is interpreted as a trigger effect on maturation of a small quantity of biologically active protein V molecules provided by UV-irradiated virus. These results are comfirmed by rescue of ts V45 by UV-irradiated, defective, interferring T particles.
摘要
感染水疱性口炎病毒（VSV）互补组V温度敏感（ts）突变体的细胞，在与紫外线照射的病毒共感染或超感染时，在非允许温度下产量会提高。在这些混合感染中产生的病毒粒子对温度敏感，并且不能互补ts V45。V组突变体的拯救是多倍体依赖性的。它可以在环己酰亚胺存在的情况下发生；在药物不存在或存在的情况下，拯救的动力学相似。拯救是由于非遗传互补，并且被解释为对紫外线照射的病毒提供的少量生物活性蛋白V分子成熟的触发作用。这些结果通过紫外线照射的、有缺陷的、干扰性T颗粒对ts V45的拯救得到证实。
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