Tay Yong-Kwang, Kwok Colin, Tan Eileen
Division of Dermatology, Changi General Hospital, 2 Simei Street 3, Singapore.
Lasers Surg Med. 2006 Mar;38(3):196-9. doi: 10.1002/lsm.20281.
Striae distensae are dermal scars with flattening and atrophy of the epidermis. Successful treatment of these stretch marks has been disappointing. The non-ablative 1,450-nm diode laser has been shown to improve atrophic scars and may be expected to improve striae. As yet, no study has been published to document the effects of this laser on striae. Our aim is to evaluate the efficacy of the 1,450-nm diode laser in the treatment of striae rubra and striae alba in Asian patients with skin types 4-6.
STUDY DESIGN/MATERIALS AND METHODS: Striae on one half of the body in 11 patients were treated with the 1,450-nm diode laser with cryogen cooling spray with the other half serving as a control. The following parameters were used: 6 mm spot size and dynamic cooling device (DCD) for 40 milliseconds to protect the epidermis. Patients were randomly assigned to receive either 4, 8, or 12 J/cm2. A total of three treatments were given at 6-week intervals. The following sites were treated: abdomen, arms, back, buttocks, and thighs. Two patients had striae rubra and nine striae alba. Clinical photographs were taken before and after each treatment and analysis was undertaken through photographic evaluation by non-treating physicians.
At 2 months after the last treatment, no patients showed any noticeable improvement in the striae on the treated side compared to baseline and to the control areas. Side effects were limited to transient erythema and postinflammatory hyperpigmentation (PIH), which occurred in seven (64%) patients.
The non-ablative 1,450-nm diode laser is not useful in the treatment of striae in patients with skin types 4, 5, and 6.
膨胀纹是伴有表皮扁平化及萎缩的皮肤瘢痕。这些妊娠纹的成功治疗一直不尽人意。非剥脱性1450纳米二极管激光已被证明可改善萎缩性瘢痕,有望改善膨胀纹。然而,尚无研究发表来记录这种激光对膨胀纹的影响。我们的目的是评估1450纳米二极管激光对亚洲4 - 6型皮肤患者的红色妊娠纹和白色妊娠纹的治疗效果。
研究设计/材料与方法:11例患者身体一侧的膨胀纹用1450纳米二极管激光及冷冻剂冷却喷雾进行治疗,另一侧作为对照。使用以下参数:光斑大小6毫米,动态冷却装置(DCD)作用40毫秒以保护表皮。患者被随机分配接受4、8或12焦耳/平方厘米的剂量。共进行三次治疗,间隔6周。治疗部位包括:腹部、手臂、背部、臀部和大腿。2例患者有红色妊娠纹,9例有白色妊娠纹。每次治疗前后均拍摄临床照片,并由非治疗医生通过照片评估进行分析。
在最后一次治疗后2个月,与基线和对照区域相比,没有患者治疗侧的膨胀纹有任何明显改善。副作用仅限于短暂性红斑和炎症后色素沉着(PIH),7例(64%)患者出现此情况。
非剥脱性1450纳米二极管激光对4、5和6型皮肤患者的膨胀纹治疗无效。